Family Marriage Problems

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The greater the ratio of cousin marriages among the parents of an affected individual, the disease prevailing would be rarer; similarly the closer the relation between parents (inbreeding) i.e. first or second cousin, the drastic the outcome. Rendering to the data collected from a number of studies, it has been observed that 11.7 per cent (25/213) of progeny from cousin marriages presented autosomal recessive disorders, 11.7 per cent (25/213) showed nonspecific severe intellectual impairment, 16 per cent (34/213) exhibited congenital malformations and 14.6 per cent (31/213) bared mild intellectual impairment.

Furthermore, susceptibility to infectious diseases i.e. hepatitis and tuberculosis is elevated in occasions of inbreeding. Consanguinity is also related to homozygosity and childhood mortality which results from invasive bacterial disease.

Mortality in offspring of first cousin and non-consanguineous marriages in Brazil (average of 8 populations), Pakistan (average of 9 populations), India (average of 10 populations), Japan (average of 7 populations) and France (average of 2 populations).

To investigate the relationships between consanguinity, fertility and rate of mortality, data on 9520 families resident in 11 cities in the province of Punjab, Pakistan, were obtained in studies conducted between 1979 and 1985. Total pregnancies and number of live births per mother by consanguinity class.Proportion of deaths by age interval and consanguinity class.D1C: Double first cousin; 1C: First cousin; 1.5C/D2C: first cousin once removed/double second cousin; 2C: Second cousin; NC: Non- consanguineous.Consequently, the burden and challenge of such genetic disorders in this population calls for the establishment of prevention programs. Strategies like genetic counseling; screening and pre-natal diagnosis strategies require epidemiological surveys, which include information regarding the types and prevalence of various genetic disorders along with family history. Thus newly married couples should go for counseling related to genetic disorders prevailing in the population so that incidents may be reduced. The writer is associated with the National Center of Excellence in Molecular Biology, University of the Punjab. She can be reached at. ( with Thanks )Genetic disorder, avoid family marriages to dodge , THALASSEMIA

ISLAMABAD: Thalassemia is a genetically transmitted blood disorder and its further proliferation could only be slashed down by avoiding intra-family marriages.

Dr Wasim Khawaja, a spokesman for Pakistan Institute of Medical Sciences told APP that there are 10 million carriers of this disease who transmit it to the next generation.

Economic cost of thalassemia treatment is enormous. Experts say around 8,000 children are born with thalassemia every year. Thalassemia experts say almost seven per 100 people are thalassemia-minor patients in Pakistan and they are the ‘carriers’ of the disease.

The carriers are normal themselves and may not even know about their inborn disease until tested, but have the potential to transmit it to their offspring when they marry a carrier, producing a thalassemia major child.

 Ayesha Abid of Thalassemia Awareness and Prevention in Pakistan called upon the government to set up thalassemia centres to ensure blood transfusion services to the deserving patients.

Published in The Express Tribune, November 19th, 2012. Family Marriage Problems and  ‘ATTHRAH ‘ (childhood diseases)  with herbal treatment. 

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